The standard equation for a line is
where (h.k) is the center and r is the radius.
(4,1) lies on the circle, so
Call that eq: 1.
(6,5) lies on the circle, so
Call that eq: 2
(h,k) is the center of the circle, and therefore must lie on the line that passes through the center. 4h + k = 16 and thus k = 16-4h eq: 3
Set 1 = 2 since both = r squared. 
Expand the squared binomials:
.
Subtract h squared and k squared from both sides, and combine like terms.
17 - 8h - 2k = 61 -12h - 10k
4h = 44 - 8k so h = 11-2k Substitute that into eq:3 and solve it for k
k = 16 - 4(11-2k) = 16 - 44 +8k = 28+8k
-7k =28
k = -4
h = 11-2k = 11-2(-4) = 11+8 = 19.
The center of the circle is (19,-4) and thus the equation is:
Use one of the given points to find r. Use (4,1).

The equation is 
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