Question 1036090
Well, the word statistics has 10 letters. 
So, the first word can use any of the ten letters. You have 10 choices. 
10 x __ x __ x __ x __ x __
The second letter can't be the letter you chose. That leaves you with 9 choices. 
10 x 9 x __ x __ x __ x __
The last letter is a consonant. I'm not sure if you mean a consonant in the word statistic or any consonant, so if it's from the word statistic, you'd have 3 choices. If you mean any consonant from the alphabet, you'd have 21 choices. 
10 x 9 x 3 OR 21 x __ x __ x __ 
The last three digits are lower than five so you have 5 choices. 0,1,2,3,4. 
10 x 9 x 3 OR 21 x 5 x 5 x 5 
Multiply them all together and that's your answer!
Hope this helps(: