Question 167695
simplify 
(5x+1)^2(4x-4)^2
---------------
= 4*((5x+1)*(x-1))^2
That's as simplified as it gets.  "simplify" needs to be defined.  
If you meant to expand it:
= {{{(25x^2+10x+1)*(16x^2-32x+16)}}}
= {{{400x^4 - 640x^3 + 96x^2 + 128x + 16}}}