We need to find the equation of the circle that has its
center as the midpoint between (2,-1) and (6,-5), the green circle below:
Midpoint between (2,-1) and (6,-5), 

= (4,-3)
and has its diameter as the distance between between (2,-1) and (6,-5)
and its radius as half that:
Therefore its center is (4,-3) and its
radius is one-half the diameter
.
Its equation is
Or you can multiply it out and rearrange to get this:
Edwin