Question 758602: Multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient’s own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.
Patient 1 2 3 4 5 6 7
Before 158 189 202 353 416 426 441
After 284 214 101 227 290 176 290
At the .01 level of significance, is there sufficient evidence to conclude that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?
A. No
B. Yes
C. Cannot Determine
Answer by stanbon(75887)   (Show Source):
You can put this solution on YOUR website! Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.
Patient 1 2 3 4 5 6 7
Before 158 189 202 353 416 426 44
After 284 214 101 227 290 176 290
Dif(A-B)-126 -25 101 126 126 250 151
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mean of Dif: 86.14
std of Dif:: 123.7
At the .01 level of significance, is there sufficient evidence to conclude that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?
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Ho: ud = 0
H1: ud > 0 (claim)
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t(86.14) = (86.14/[123.7/sqrt(7)) = 1.8424
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p-value = P(t > 1.8424 when df = 6) = tcdf(1.8424,100,6) = 0.0575
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Conclusion: Since the p-value is greater than 1%, fail to reject Ho at
the 1% level of significance.
Ans:: No
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Cheers,
Stan H.
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