To get a term independent of x, you need to take the "2x^3" term from 5 of the factors and the "1/(4x^5)" term from the other 3 factors. So the term is
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tutor ikleyn has pointed out that I lost track of a sign in the above response....
The "1/4x^5" term in the binomial is negative, so the constant term is
The binomial expansion is this formula
= + + + + . . . + +
In our case, n = 8, a = , b = -, therefore, the binomial expansion in our case is
= + + + + . . . + + .
The general term of this expansion is = = .
The term independent of x is at 3*(8-k) - 5k = 0, or
24 - 3k - 5k = 0 ====> 24 = 8k ====> k = 3 (the fourth term).
Then the coefficient at this term is = = = -28.
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The solution by @greenestamps giving the answer "28" contains an error.