The fact that half-life is 1599 years means that M(t) = M*2^(-t/1599)), (1) where M is the initial mass of the isotope, M(t) is its current mass at the current time moment t. Indeed, at t = 1599 years you have from the formula (1) M(1599) =. Then at t = 1000 years the remaining mass of the initial 10 grams is M(1000) = 10*2^(-1000/1599) = = 10*0.6482 = 6.482 grams. Answer. 6.482 grams of the isotope after 1000 years.