Lesson A medication decay in a human's body

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A medication decay in a human's body


Problem 1

A certain pain reliever has a half-life of  16  hours.  If the initial plasma level of this pain reliever,
given as a single dose,  is  512 mg/L,  how long will it take for the plasma level to fall to  16 mg/L?

Solution

Notice that the ratio of  16 mg/L  to  512 mg/L  is  16%2F512 = 1%2F32 = 1%2F2%5E5.


It means that after  5  (five)  half-life periods the original concentration 

of the drug in the plasma will decrease from the original  512 mg/L  to  16 mg/L.


So, the ANSWER to the problem's question is  5 times half-life periods, or 5 x 16 hours = 80 hours.

Problem 2

Paracetamol is a drug used to treat mild to moderate pain and to reduce fever.  It has a half-life in the body of 3 hours.
Under a  Doctor's  care,  patient  N  is given a dose of a certain paracetamol.  Patient  N  asks the doctor for another same dose
of this paracetamol.  The doctor agrees to allow patient  N  to take dose once there is only  6.25%  of the original dose
remaining in the body.  How long will patient  N  have to wait,  before taking another dose of this paracetamol?

Solution

Notice that  6.25%  is  this ratio  6.25%2F100 = 1%2F16 = 1%2F2%5E4.


It means that after 4 (four) half-life periods the amount of the drug in the body will reach 6.25% of the original level.


So, the ANSWER to the problem's question is  4 times the half-life period, or 4 x 3 hours = 12 hours.

Problem 3

Coffee contains caffeine.  The half-life of caffeine is  5  hours.  This means the amount of caffeine
in your bloodstream is reduced by  50%  every  5  hours.  Suppose you drink a cup of coffee that contains  320  mg of caffeine.
How long will it take until there is  5  mg of caffeine left in your bloodstream?

Solution

Notice that the ratio of  320 mg of caffeine  to  5 mg of caffeine  is  5%2F320 = 1%2F64 = 1%2F2%5E6.


It means that after 6 (six) half-life periods the original amount of the caffeine

of the bloodstream will decrease from the original  420 mg  to  5 mg/L.


So, the ANSWER to the problem's question is  6 times the half-life period, or 6 x 5 hours = 30 hours.

Problem 4

A drug is eliminated from the body through urine.  Suppose that for a dose of  200  milligrams,
the amount remaining in the body  4  hours later is  100  milligrams:
Find an exponential model that gives the amount of medicine left in the body after t hours.

Solution

The original amount was 200mg, and the half-life period of elimination from the body is 4 hours.

It means that the number of milligrams of the drug remaining in the body after t hours  is  200%2A%281%2F2%29%5E%28t%2F4%29.    ANSWER

Problem 5

What is the maximum and minimum amount of a drug remaining in a patient's body after long time
(that is,  as time tends to infinity)  given that the patient takes an  80  milligram dose once a day at the same time
each day and the drug has a half life of  22  hours?

Solution

The maximum amount  d%5Bmax%5D  is the sum of the infinite Geom. progression 

with the first term  "a" = 80 milligrams  and the common ratio  r = 0.5^(24/22) = 0.469465


     d%5Bmax%5D = a%2F%281-r%29 = 80%2F%281-0.469465%29 = 150.7913  milligrams.


The minimum amount  d%5Bmin%5D  is 80 milligrams less than d%5Bmax%5D, i.e  d%5Bmin%5D = 70.7913  milligrams.


As the time becomes very large, the process (the plot of the function d(t)) is periodical with the period of time equal to 24 hours.


My other lessons in this site on logarithms,  logarithmic equations and relevant word problems are
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    - Properties of the logarithm,
    - Change of Base Formula for logarithms,
    - Evaluate logarithms without using a calculator
    - Simplifying expressions with logarithms
    - Solving logarithmic equations,
    - Solving advanced logarithmic equations
    - Solving really interesting and educative problem on logarithmic equation containing a HUGE underwater stone
    - Proving equalities with logarithms
    - Solving logarithmic inequalities
    - Using logarithms to solve real world problems,  and
    - Solving problem on Newton Law of cooling
    - Population growth problems
    - Radioactive decay problems
    - Carbon dating problems
    - Bacteria growth problems
    - Problems on appreciated/depreciated values
    - Inflation and Salary problems
    - Miscellaneous problems on exponential growth/decay
    - Problems on discretely compound accounts
    - Problems on continuously compound accounts
    - Tricky problem on solving a logarithmic system of equations
    - Entertainment problem: Uninterrupted withdrawing money from a retirement fund
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    - Upper level problems on solving logarithmic equations
    - OVERVIEW of lessons on logarithms, logarithmic equations and relevant word problems

Use this file/link  ALGEBRA-I - YOUR ONLINE TEXTBOOK  to navigate over all topics and lessons of the online textbook  ALGEBRA-I.


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