ZWYX
We cannot do it in only two changes because these
WZYX, ZYWX, ZWXY, XYWZ
are the only possible results after one change, and the
final result of WXYZ cannot be obtained from any of these
in only one additional change.
However we can change ZYWX to ZYXW to WXYZ,
or
we can change XYWZ to XWYZ to WXYZ.
So the least number of changes possible is 3.
Edwin