We can choose the first digit as 4, 5, or 6. That's 3 ways.
We can choose the second digit as any of the remaining 4 ways.
We can choose the third digit as any of the remaining 3 ways.
We can choose the fourth digit as either of the remaining 2 ways.
We must choose the fifth digit as the only remaining 1 way.
Answer: 3 = 48 ways.
Edwin