.
As I understand the question, it is not about real letters for blind persons.
It is about abstract "letters", that are defined as different combinations of raised dots on a given surface.
The number of different combinations of raised dots is equal to the number of all subsets of the set of 5 elements.
It is well known fact that the number of all subsets of any finite set of N elements is
, incliding
the empty subset and the proper subset.
Since the empty subset is excluded by the condition, we have for N= 5 given braille dots
= 32-1 = 31 possible non-empty subsets,
and, hence, 31 possible "abstract" letters.
Solved.
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For discussion and the proof of this formula
for the number of subsets of the given finite set of N elements, see the lesson
- How many subsets are there in a given finite set of n elements?
in this site.