Question 1184681: Oexle et al. (A-7) calculated the negative predictive value of a test for carriers of X-linked ornithine transcarbamylase deficiency (OTCD—a disorder of the urea cycle). A test known as the“allopurinol test” is often used as a screening device of potential carriers whose relatives are OTCD patients.
They cited a study by Brusilow and Horwich (A-8) that estimated the sensitivity of the allopurinol test as .927. Oexle et al. themselves estimated the specificity of the allopurinol test as .997. Also they estimated the prevalence in the population of individuals with OTCD as 1/32000. Use this information and Bayes’s theorem to calculate the predictive value negative of the allopurinol screening test.
Answer by ikleyn(52814)   (Show Source):
You can put this solution on YOUR website! .
Oexle et al. (A-7) calculated the negative predictive value of a test for carriers of X-linked ornithine transcarbamylase deficiency
(OTCD—a disorder of the urea cycle). A test known as the“allopurinol test” is often used as a screening device of potential carriers
whose relatives are OTCD patients.
They cited a study by Brusilow and Horwich (A-8) that estimated the sensitivity of the allopurinol test as .927. Oexle et al.
themselves estimated the specificity of the allopurinol test as .997. Also they estimated the prevalence in the population
of individuals with OTCD as 1/32000. Use this information and Bayes’s theorem to calculate the predictive value
negative of the allopurinol screening test.
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If your goal was to make an impression and to demonstrate how smart you are using so many specialized terms,
I'd say you achieved your goal.
But I am not so smart and not so educated, UNFORTUNATELY, to understand your terminology.
So, look and seek for another site/forum for help.
I wish you to have and to keep the sense of proportion, when you post your messages,
especially when you post to this forum . . .
Ancient Greeks considered the sense of proportion as very important part of the human common sense
and an important feature of Homo sapience, in a line / (on a par) with other human feelings . . .
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