document.write( "<A HREF=/cgi-bin/jump-to-question.mpl?question=758602>Question 758602</A>: <I><SPAN STYLE=\"word-break: break-all;\"> Multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient’s own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.\r<BR>\n" );
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document.write( "Patient	1	2	3	4	5	6	7<BR>\n" );
document.write( "Before	158	189	202	353	416	426	441<BR>\n" );
document.write( "After	284	214	101	227	290	176	290\r<BR>\n" );
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document.write( "At the .01 level of significance, is there sufficient evidence to conclude that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?<BR>\n" );
document.write( "A. No<BR>\n" );
document.write( "B. Yes<BR>\n" );
document.write( "C. Cannot Determine\r<BR>\n" );
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document.write( "</I><HR><TABLE width=100%><TR><TD><B><A HREF=http://www.algebra.com/>Algebra.Com's</A> Answer #461631 by </B><A HREF=/tutors/aboutme.mpl?userid=stanbon><B>stanbon(75887)</B></A><img src=\"/images/stars/stars-13.gif\" alt=\"\" >&nbsp;<A HREF=/tutors/aboutme.mpl?userid=stanbon><IMG SRC=http://www.algebra.com/images/aboutme-small.gif BORDER=0 alt=\"About Me\" VALIGN=MIDDLE></A>&nbsp;<IMG SRC=http://www.algebra.com/images/nopicture.jpg><BR>You can <A HREF=\"/cgi-bin/embed-solution.mpl?show=1&solution=461631\">put this solution on YOUR website!</A><BR><SPAN STYLE=\"word-break: break-all;\"> Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.\r<BR>\n" );
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document.write( "Patient	1	2	3	4	5	6	7<BR>\n" );
document.write( "Before	158	189	202	353	416	426	44<BR>\n" );
document.write( "After	284	214	101	227	290	176	290<BR>\n" );
document.write( "Dif(A-B)-126     -25      101      126      126     250      151<BR>\n" );
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document.write( "mean of Dif: 86.14<BR>\n" );
document.write( "std of Dif:: 123.7    \r<BR>\n" );
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document.write( "At the .01 level of significance, is there sufficient evidence to conclude that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?<BR>\n" );
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document.write( "Ho: ud = 0<BR>\n" );
document.write( "H1: ud > 0 (claim)<BR>\n" );
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document.write( "t(86.14) = (86.14/[123.7/sqrt(7)) = 1.8424<BR>\n" );
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document.write( "p-value = P(t > 1.8424 when df = 6) = tcdf(1.8424,100,6) = 0.0575<BR>\n" );
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document.write( "Conclusion: Since the p-value is greater than 1%, fail to reject Ho at<BR>\n" );
document.write( "the 1% level of significance.\r<BR>\n" );
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document.write( "Ans:: No<BR>\n" );
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document.write( "Cheers,<BR>\n" );
document.write( "Stan H.<BR>\n" );
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