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, so

.
Since we are interested in when and where they meet, their drive times must be equal.
Let's say that x is the distance Bob drives at 45 mph. That means that the distance Joe drives at 65 mph is 243 - x.
Using

, Bob's drive time is

, and Joe's drive time is

. But we already determined that these drive times are equal so we can say:
Cross multiply:
From here on out, '=' means 'approximately equal to'

, or Bob drove

miles to the meeting point.
Since we know that

, Bob's travel time must be

or

hours.

hours is

minutes, and since they started at straight up noon, they must have met at 2:12.6 PM, and they met 99.41 miles from Bob's starting point.
Check:
Since they met at 99.41 miles from Bob's starting point, they must have met 243 - 99.41 = 143.59 miles from Joe's starting point. If Joe travelled for 2.21 hours at 65 mph, he travelled

miles. Answer checks. (Actually, if you just plug in the numbers given, the calculator shows a bit of error, but if you do the arithmetic from the beginning on the calculator and never round off until the end, it all comes out correctly)