The triangle is right-angled with the legs DE (horizontal) and DF (vertical). Hence, the circumcenter is the mid-point of the hypotenuse EF, i.e. the point (4,3).
The circumcenter is where the perpendicular bisectors of the sides intersect. Two of them are very easy to draw, since the longer leg is horizontal and the shorter one is vertical. I'll draw them in green: So you can see it's C(4,3). Edwin