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!r!}})
Start with the given formula
!8!}})
Plug in

and

Subtract

to get 2

Calculate 10! to get 3,628,800 (note: if you need help with factorials, check out this
solver)
(8!)}})
Calculate 2! to get 2
(40320)}})
Calculate 8! to get 40,320

Multiply the values 2 and 40,320 to get 80,640

Divide 3,628,800 by 80,640 to get 45
So 10 choose 8 (where order does not matter) yields 45 unique combinations