The Rth term in the expansion of (A + B)N is C(N,R-1)AN-R+1BR-1. Therefore substituting A=2x, B=-1, N=6, R=4, C(6,4-1)(2x)6-4+1(-1)4-1. C(6,3)(2x)3(-1)3. 20(2x)3(-1). 20(23x3)(-1). 20(8x3)(-1). -160x3. Edwin