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How many ways can the letters of the word MISSISSIPPI be arranged if no two S's are side by side?
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Since you use the term "arranged", I will assume that you know the difference between permutations and arrangements,
and between distinguishable and undistinguishable arrangements/permutations.
First, take off all letters S from the word. You will get
MIIIPPI
Next, insert blanks between the remaining letters. Also, place blanks before the first letter and after last letter.
You will get
_M_I_I_I_P_P_I_
with 8 blanks.
Now you have 7-letters word MIIIPPI with 4 repeating letter I and 2 repeating letters P.
You can arrange them in = = 105 distinguishable ways. (1)
Finally, you distribute four letters S, one after one, among 8 blank positions, placing one S into one blank.
You can do it by = = 70 ways. (2)
Now, combining 105 arrangements (1) with 70 independent arrangements (2), you have 105*70 = 7350 total possible arrangements
of the word MISSISSIPPI with no two S's side by side.
Solved.