The y-intercept is where the line (or curve) crosses the y-axis. Mathematically, if you have y = some_function_of_x then it is the y value when you set x=0.
OPTIONAL:
For example, when dealing with straight lines, the equation of the line is often written y = mx + b where m=slope (the rise/run or (change in y) / (change in x)) and b is the y-intercept.
Below is the graph of y = 2x-5 in green. Notice how the line meets the y-axis at -5: